منابع مشابه
A Convoluted Way to Die
velopment is initiated by transcriptional upregulation of Ivelisse Sánchez and Junying Yuan* Egl-1, another BH3-only member of the BCL-2 family Department of Cell Biology that acts by inhibiting Ced-9, an antiapoptotic member Harvard Medical School of the BCL-2 family (Conradt and Horvitz, 1998). 240 Longwood Avenue BIM may not be the only BH3-only member that is Boston, Massachusetts 02115 ind...
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TRAIL, a putative anticancer cytokine, induces extrinsic cell death by activating the caspase cascade directly (Type I cells) via the death-inducing signaling complex (DISC) or indirectly (Type II cells) by caspase-8 cleavage of Bid and activation of the mitochondrial cell death pathway. Cancer cells are characterized by their dependence on aerobic glycolysis, which, although inefficient in ter...
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Granzyme A (GzmA) is the most abundant serine protease in killer cell cytotoxic granules. GzmA activates a novel programed cell death pathway that begins in the mitochondrion, where cleavage of NDUFS3 in electron transport complex I disrupts mitochondrial metabolism and generates reactive oxygen species (ROS). ROS drives the endoplasmic reticulum-associated SET complex into the nucleus, where i...
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When mitochondria are exposed to high Ca2+ concentrations, especially when accompanied by oxidative stress and adenine nucleotide depletion, they undergo massive swelling and become uncoupled. This occurs as a result of the opening of a non-specific pore in the inner mitochondrial membrane, known as the MPTP (mitochondrial permeability transition pore). If the pore remains open, cells cannot ma...
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The main purpose of this paper is to use a new way to extend fuzzy implications $I$ from a generalized sublattice $M$ to a bounded lattice $L$, such that the extended implications preserve many of the considered properties of fuzzy implications on $M$.Furthermore, as a special case, we investigate the extension of $(S,N)-$implications. Results indicate that the extended implications preserve ma...
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ژورنال
عنوان ژورنال: Neuron
سال: 2001
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(01)00232-x